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KMID : 1145120220200040451
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Asian Journal of Beauty and Cosmetology
2022 Volume.20 No. 4 p.451 ~ p.459
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Effects of ‘NEOGEN V.BIOME LIPOSOME™’ on the Increased Expression of COL1A1 and HAS2 mRNA in Human Dermal Fibroblasts
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Joo Ye Eun
Kwon Seung-Bin
Kwon Yu-Jeong
An In-Sook
Choi Young-Wook
Kim Mi-Jung
Sun Mei-Ling
Ahn Kyu-Joong
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Abstract
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Purpose : This study investigated functional cosmetic agent for anti-wrinkle effects of 'NEOGEN V.BIOME LIPOSOME™', which is a liposome in the form of a proprietary technology including a vitamin C active ingredient, on human dermal fibroblasts (HDFs).
Methods : The cytotoxicity of 'NEOGEN V.BIOME LIPOSOME™' was measured by performing a water-soluble tetrazolium salt (WST-1) assay. The relative mRNA expression of collagen (COL1A1) and hyaluronan synthase (HAS2) was measured by quantitative real-time PCR (qRT-PCR) assay.
Results : HDF cell viability of 'NEOGEN V.BIOME LIPOSOME™' was no cytotoxic effect at concentrations below 0.25%. The expression of COL1A1 and HAS2 mRNA was increased in a concentration-dependent manner compared with the negative control group.
Conclusion : “NEOGEN V.BIOME LIPOSOME™“ helps to increase collagen and hyaluronan synthase production by promoting COL1A1 and HAS2 mRNA expression in HDFs; therefore, it is expected to function as an anti-wrinkle cosmetic material.
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KEYWORD
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Liposome, Collagen, Hyaluronic acid, COL1A1, HAS2
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